Locus: AIB1

Topic: Protein Binding

Estrogen receptor - Anzick SL. Kononen J. Walker RL. Azorsa DO. Tanner MM. Guan XY. Sauter G. Kallioniemi OP. Trent JM. Meltzer PS. Science 277: 965-968 (1997)  [RAB]

Locus: APC

Topic: Protein Binding

	Catenin An adherence junction protein. - Akiyama T. Nippon Rinsho 54: 955-959 (1996)  [RAB]
	Self, to form oligomers - Su LK. Johnson KA. Smith KJ. Hill DE. Vogelstein B. Kinzler KW. Cancer Res 53: 2728-2731 (1993)  [RAB]
	Truncated APC proteins Truncated APC proteins can associate with wildtype protein in vivo. - Su LK. Johnson KA. Smith KJ. Hill DE. Vogelstein B. Kinzler KW. Cancer Res 53: 2728-2731 (1993)  [RAB]

Locus: BCL2

Topic: Protein Binding

	Bax - Hsu, Y. and Youle, R.J. J Biol Chem 272: 13829-13834 (1997)  [RAB]
	Bax - Hsu, Y. and Youle, R.J. J Biol Chem 272: 13829-13834 (1997)  [RAB]
	Self BCL-2 forms homodimers. - Hsu, Y. and Youle, R.J. J Biol Chem 272: 13829-13834 (1997)  [RAB]
	Calcineurin - Shibasaki, F., Kondo, E., Akagi, T. and McKeon, F. Nature 386: 728-731 (1997)  [RAB]

Locus: BRCA1

Topic: Protein Binding

	RNA polymerase II - Scully R. Anderson SF. Chao DM. Wei W. Ye L. Young RA. Livingston DM. Parvin JD. Proc Natl Acad Sci U S A 94: 5605-5610 (1997)  [RAB]
	hRad51 hRad51 is the human homologue of bacterial RecA. - Scully R. Chen J. Plug A. Xiao Y. Weaver D. Feunteun J. Ashley T. Livingston DM. Cell 88: 265-275 (1997)  [RAB]
	BARD1 BARD1 = BRCA1-associated RING domain interacts with N-terminus of BRCA1. - Wu LC. Wang ZW. Tsan JT. Spillman MA. Phung A. Xu XL. Yang MC. Hwang LY. Bowcock AM. Baer R. Nat Genet 14: 430-440 (1996)  [RAB]
	Cyclin-dependent kinase 2 - Chen Y. Farmer AA. Chen CF. Jones DC. Chen PL. Lee WH. Cancer Res 56: 3168-3172 (1996)  [RAB]
	Importin-alpha Importin-alpha is a subunit of the nuclear transport signal receptor. - Chen CF. Li S. Chen Y. Chen PL. Sharp ZD. Lee WH. J Biol Chem 271: 32863-32868 (1996)  [RAB]

Locus: BRCA2

Topic: Protein Binding

MmRad51 Amino acids 1-43 are essential for the interaction. - Sharan, S.K., Morimatsu, M., Albrecht, U., Lim, D., Regel, E., Dinh, C., Sands, A., Eichele, G., Hasty, P. and Bradley, A. Nature 386: 804-810 (1997)  [RAB]

Locus: CCND1

Topic: Protein Binding

	p34 (cdk4) - Altucci L. Addeo R. Cicatiello L. Dauvois S. Parker MG. Truss M. Beato M. Sica V. Bresciani F. Weisz A. Oncogene 12: 2315-2324 (1996)  [RAB]
	p32 (cdk2) - Altucci L. Addeo R. Cicatiello L. Dauvois S. Parker MG. Truss M. Beato M. Sica V. Bresciani F. Weisz A. Oncogene 12: 2315-2324 (1996)  [RAB]
	cdk4 - Said TK. Luo L. Medina D. Carcinogenesis 16: 2507-2513 (1995)  [RAB]

Locus: ERBB2

Topic: Protein Binding

AIB1 AIB1 = protein encoded by Amplified in Breast Cancer-1 gene. - Anzick SL. Kononen J. Walker RL. Azorsa DO. Tanner MM. Guan XY. Sauter G. Kallioniemi OP. Trent JM. Meltzer PS. Science 277: 965-968 (1997)  [RAB]

Locus: ERBB3

Topic: Protein Binding

	Neuregulin-2 Neuregulin-2 is a ligand for erbB3. - Carraway III, K.L., Weber, J.L., Unger, M.J., Ledesma, J., Yu, N., Gassmann M., and Lai, C. Nature 387: 512-516 (1997)  [RAB]
	p85 regulatory subunit of PI3K PI3K = Phosphatidylinositol 3-kinase. Binding is induced by heregulin during mitogenesis. - Ram TG. Ethier SP. Cell Growth Differ 7: 551-561 (1996)  [RAB]
	PI3K Association of erbB3 with PI3K is stimulated by recombinant HRG beta 2. PI3K = phosphatidylinositol-3-kinase. - Fiddes RJ. Janes PW. Sanderson GM. Sivertsen SP. Sutherland RL. Daly RJ. Cell Growth Differ 6: 1567-1577 (1995)  [SSC]
	ErbB-2 Heterodimerizes with erbB-2. - Alimandi M. Romano A. Curia MC. Muraro R. Fedi P. Aaronson SA. Di Fiore PP. Kraus MH. Oncogene 10: 1813-1821 (1995)  [RAB]

Locus: ESR1

Topic: Protein Binding

c-Raf-1 - Winkler DG. Johnson JC. Cooper JA. Vojtek AB. J Biol Chem 272: 24113-24116 (1997)  [RAB]

Locus: HRAS

Topic: Protein Binding

Of stem cell factor ligand Also known as kit ligand, steel factor or mast cell growth factor. - Costa JJ. Demetri GD. Harrist TJ. Dvorak AM. Hayes DF. Merica EA. Menchaca DM. Gringeri AJ. Schwartz LB. Galli SJ. J Exp Med 183: 2681-2686 (1996)  [RAB]

Locus: KIT

Topic: Protein Binding

	TBP Binding is at the central acidic domain of the MDM2 protein. - Leveillard T. Wasylyk B. J Biol Chem 272: 30651-30661 (1997)  [RAB]
	TAFII250 Binding occurs at the C-terminal Ring finger of the MDM2 protein. - Leveillard T. Wasylyk B. J Biol Chem 272: 30651-30661 (1997)  [RAB]
	p53, residues 13-29 - Levine, A.J. Cell 88: 323-331 (1997)  [RAB]
	Isoform p76/74 doesn't interact with p53. Study of bronchogenic carcinomas. - Gorgoulis VG. Zoumpourlis V. Rassidakis GZ. Karameris A. Rassidakis AN. Spandidos DA. Kittas C. J Pathol 180: 129-137 (1996)  [RAB]
	L5 ribosomal protein And its associated 5S ribosomal RNA. - Elenbaas B. Dobbelstein M. Roth J. Shenk T. Levine AJ. Mol Med 2: 439-451 (1996)  [RAB]
	12 & 15mer peptides with homology to p53 18TFSDLW23 These peptides were identified by phage display. - Bottger V. Bottger A. Howard SF. Picksley SM. Chene P. Garcia-Echeverria C. Hochkeppel HK. Lane DP. Oncogene 13: 2141-2147 (1996)  [RAB]
	Transcription factor DP1 - Martin K. Trouche D. Hagemeier C. Sorensen TS. La Thangue NB. Kouzarides T. Nature 375: 691-694 (1995)  [RAB]
	Transcription factor E2F1 - Martin K. Trouche D. Hagemeier C. Sorensen TS. La Thangue NB. Kouzarides T. Nature 375: 691-694 (1995)  [RAB]
	pRB - Xiao ZX. Chen J. Levine AJ. Modjtahedi N. Xing J. Sellers WR. Livingston DM. Nature 375: 694-698 (1995)  [RAB]
	p53 acidic activation domain - Oliner JD. Pietenpol JA. Thiagalingam S. Gyuris J. Kinzler KW. Vogelstein B. Nature 362: 857-860 (1993)  [RAB]
	Protein residues 1-58 & 155-221 bind p53 - Brown DR. Deb S. Munoz RM. Subler MA. Deb SP. Mol Cell Biol 13: 6849-6857 (1993)  [RAB]
	Simian virus 40 T antigen - Brown DR. Deb S. Munoz RM. Subler MA. Deb SP. Mol Cell Biol 13: 6849-6857 (1993)  [RAB]
	p53 - Oliner JD. Kinzler KW. Meltzer PS. George DL. Vogelstein B. Nature 358: 80-83 (1992)  [RAB]

Locus: MDM2

Topic: Protein Binding

Rb - Goodrich DW. Lee WH. Nature 360: 177-179 (1992)  [RAB]

Locus: MYC

Topic: Protein Binding

	gp30 gp30 is a putative ligand for ERBB-2. - Saceda M. Grunt TW. Colomer R. Lippman ME. Lupu R. Martin MB. Endocrinology 137: 4322-4330 (1996)  [RAB]
	p85 regulatory subunit of PI3K PI3K = Phosphatidylinositol 3-kinase. Binding is induced by heregulin during mitogenesis and is constitutively elevated in breast cancer cells with c-erbB-2 gene amplification. - Ram TG. Ethier SP. Cell Growth Differ 7: 551-561 (1996)  [RAB]
	NDF receptors (ErbB-3 & ErbB-4) - Karunagaran D. Tzahar E. Beerli RR. Chen X. Graus-Porta D. Ratzkin BJ. Seger R. Hynes NE. Yarden Y. EMBO J 15: 254-264 (1996)  [RAB]
	EGF receptor (ErbB-1) - Karunagaran D. Tzahar E. Beerli RR. Chen X. Graus-Porta D. Ratzkin BJ. Seger R. Hynes NE. Yarden Y. EMBO J 15: 254-264 (1996)  [RAB]
	Binds GRP94 In vivo - Chavany C. Mimnaugh E. Miller P. Bitton R. Nguyen P. Trepel J. Whitesell L. Schnur R. Moyer J. Neckers L. J Biol Chem 271: 4974-4977 (1996)  [RAB]
	c-Src Binding occurs when Neu is tyrosine phosphorylated. - Muthuswamy SK. Muller WJ. Oncogene 11: 1801-1810 (1995)  [RAB]
	c-Src When Neu is tyrosine phosphorylated. - Muthuswamy SK. Muller WJ. Oncogene 11: 271-279 (1995)  [RAB]
	Does NOT bind Neu differentiation factor - Graus-Porta D. Beerli RR. Hynes NE. Mol Cell Biol 15: 1182-1191 (1995)  [RAB]
	Does NOT bind epidermal growth factor - Graus-Porta D. Beerli RR. Hynes NE. Mol Cell Biol 15: 1182-1191 (1995)  [RAB]
	ErbB-3 Heterodimerizes with erbB-3. - Alimandi M. Romano A. Curia MC. Muraro R. Fedi P. Aaronson SA. Di Fiore PP. Kraus MH. Oncogene 10: 1813-1821 (1995)  [RAB]

Locus: PLG

Topic: Protein Binding

	Coactivator p300 - Gu W. Roeder RG. Cell 90: 595-606 (1997)  [RAB]
	MDM2 Amino acids G58, D68, V75 & C77 are the residues of contact. - Freedman DA. Epstein CB. Roth JC. Levine AJ. Mol Med 3: 248-259 (1997)  [RAB]
	Transcription factor TAF31 Binding occurs at the p53 amino terminus. - Levine, A.J. Cell 88: 323-331 (1997)  [RAB]
	Transcription factor TAF70 TAF70 binds to the amino terminus of p53. - Levine, A.J. Cell 88: 323-331 (1997)  [RAB]
	TATA-binding protein, TBP TBP binds to both carboxyl & amino termini of p53. - Levine, A.J. Cell 88: 323-331 (1997)  [RAB]
	MDM2 MDM2 blocks p53 transcriptional activation domain. - Levine, A.J. Cell 88: 323-331 (1997)  [RAB]
	Human papilloma virus E6 This interaction promotes the degradation of p53. - Levine, A.J. Cell 88: 323-331 (1997)  [RAB]
	Adenovirus E1B 55 kDA protein This interaction blocks p53 transcriptional activation domain. - Levine, A.J. Cell 88: 323-331 (1997)  [RAB]
	SV40 T antigen This interaction blocks p53 DNA binding domain. - Levine, A.J. Cell 88: 323-331 (1997)  [RAB]
	Wilms tumor-1 This binding occurs when both proteins are overexpressed in a cell. - Levine, A.J. Cell 88: 323-331 (1997)  [RAB]
	Transcription factor IIH helicase ERCC3 In vitro binding. Helicase ERCC3 is encoded by gene XP-B. - Levine, A.J. Cell 88: 323-331 (1997)  [RAB]
	Transcription factor IIH helicase ERCC2 In vitro binding. Helicase ERCC2 is encoded by gene XP-D. - Levine, A.J. Cell 88: 323-331 (1997)  [RAB]
	c-Abl c-Abl enhances p53 transcriptional activity. - Levine, A.J. Cell 88: 323-331 (1997)  [RAB]
	Self; to form tetramers - Levine, A.J. Cell 88: 323-331 (1997)  [RAB]
	Adenovirus E1B-55kd (Human). Amino acids 22 and 23 play a key role in the binding. - Levine, A.J. Cell 88: 323-331 (1997)  [RAB]
	Residues 22 & 23 bind MDM2 Fact pertains to human p53. - Levine, A.J. Cell 88: 323-331 (1997)  [RAB]
	Transcription factor DP-1. Binding involves C-terminus of DP-1 and N-terminal region of p53. - Sorensen TS. Girling R. Lee CW. Gannon J. Bandara LR. La Thangue NB. Mol Cell Biol 16: 5888-5895 (1996)  [RAB]
	MDMX Interaction probably involves p53 N-terminus. MDMX is a p53-binding protein with some structural similarities to MDM2. - Shvarts A. Steegenga WT. Riteco N. van Laar T. Dekker P. Bazuine M. van Ham RC. van der Houven van Oordt W. Hateboer G. van der Eb AJ. Jochemsen AG. EMBO J 15: 5349-5357 (1996)  [RAB]
	MDM2 Crystallography of the 109 amino-terminal residues of the MDM2 protein bound to a 15-residue transactivation domain peptide of p53. The p53 peptide binds to a hydrophobic cleft in MDM2. The p53 peptide binds as an amphipathic alpha helix due to steric complementarity between the MDM2 cleft and the hydrophobic face of the helix. Important p53 residues are Phe19, Trp23 & Leu26. - Kussie PH. Gorina S. Marechal V. Elenbaas B. Moreau J. Levine AJ. Pavletich NP. Science 274: 948-953 (1996)  [RAB]
	Binds topoisomeraseI Binding ocurrs in vivo and in vitro. - Gobert C. Bracco L. Rossi F. Olivier M. Tazi J. Lavelle F. Larsen AK. Riou JF. Biochemistry 35: 5778-5786 (1996)  [RAB]
	Transcription factors E2F1 & DPI - O'Connor DJ. Lam EW. Griffin S. Zhong S. Leighton LC. Burbidge SA. Lu X. EMBO J 14: 6184-6192 (1995)  [RAB]
	Mutant form binds a 38kd nuclear protein - Chen Y. Chen PL. Lee WH. Mol Cell Biol 14: 6764-6772 (1994)  [RAB]
	Mutant form binds a 42kd nuclear protein - Chen Y. Chen PL. Lee WH. Mol Cell Biol 14: 6764-6772 (1994)  [RAB]
	Residues 1-159 & 145-327 bind MDM2 - Brown DR. Deb S. Munoz RM. Subler MA. Deb SP. Mol Cell Biol 13: 6849-6857 (1993)  [RAB]

Locus: RB1

Topic: Protein Binding

	alph/beta subunits of ATP synthetase - Moser TL. Stack MS. Asplin I. Enghild JJ. H#jrup P. Everitt L. Hubchak S. Schnaper HW. Pizzo SV. Proc Natl Acad Sci U S A 96: 2811-2816 (1999)  [DLS]
	Adhesion protein vitronectin Binding sites reside in kringles 1-3. - Kost C. Benner K. Stockmann A. Linder D. Preissner KT. Eur J Biochem 236: 682-688 (1996)  [RAB]

Locus: SRC

Topic: Protein Binding

	CyclinD:Cdk4/6 complex - Ezhevsky SA. Nagahara H. Vocero-Akbani AM. Gius DR. Wei MC. Dowdy SF. Proc Natl Acad Sci U S A 94: 10699-10704 (1997)  [RAB]
	Hypophosphorylated protein interacts w E2F - Ezhevsky SA. Nagahara H. Vocero-Akbani AM. Gius DR. Wei MC. Dowdy SF. Proc Natl Acad Sci U S A 94: 10699-10704 (1997)  [RAB]
	ICE-like protease cleavage product does not bind MDM2 - Janicke RU. Walker PA. Lin XY. Porter AG. EMBO J 15: 6969-6978 (1996)  [RAB]
	Transcription factor E2F-1 E2F-1 binds Rb gene promoter and RB protein. - Shan B. Durfee T. Lee WH. Proc Natl Acad Sci U S A 93: 679-684 (1996)  [RAB]
	Transcription factor NF-IL6 - Chen PL. Riley DJ. Chen-Kiang S. Lee WH. Proc Natl Acad Sci U S A 93: 465-469 (1996)  [RAB]
	hsp75 In vitro, hsp75 refolds denatured Rb into its native conformation. - Chen CF. Chen Y. Dai K. Chen PL. Riley DJ. Lee WH. Mol Cell Biol 16: 4691-4699 (1996)  [RAB]
	MDM2 - Xiao ZX. Chen J. Levine AJ. Modjtahedi N. Xing J. Sellers WR. Livingston DM. Nature 375: 694-698 (1995)  [RAB]
	H-NUC H-NUC is the human homologue of the nuc2 of fission yeast and the bimA of Aspergillus DNA-binding proteins. - Chen PL. Ueng YC. Durfee T. Chen KC. Yang-Feng T. Lee WH. Cell Growth Differ 6: 199-210 (1995)  [RAB]
	Mitosin Mitosin is a nuclear phosphoprotein involved in mitotic-phase progression. - Zhu X. Mancini MA. Chang KH. Liu CY. Chen CF. Shan B. Jones D. Yang-Feng TL. Lee WH. Mol Cell Biol 15: 5017-5029 (1995)  [RAB]
	Self RB can self-associate and this association is mediated by interactions between the carboxy and amino termini. - Hensey CE. Hong F. Durfee T. Qian YW. Lee EY. Lee WH. J Biol Chem 269: 1380-1387 (1994)  [RAB]
	Lamin C Lamin C is a peripheral matrix protein. - Mancini MA. Shan B. Nickerson JA. Penman S. Lee WH. Proc Natl Acad Sci U S A 91: 418-422 (1994)  [RAB]
	Lamin A Lamin A is a peripheral matrix protein. - Mancini MA. Shan B. Nickerson JA. Penman S. Lee WH. Proc Natl Acad Sci U S A 91: 418-422 (1994)  [RAB]
	84 kD nuclear matrix protein This protein binds the amino terminus of the hypophosphorylated RB protein. - Durfee T. Mancini MA. Jones D. Elledge SJ. Lee WH. J Cell Biol 127: 609-622 (1994)  [RAB]
	PP-1 alpha 2 This association occurs from mitosis to early G1. - Durfee T. Becherer K. Chen PL. Yeh SH. Yang Y. Kilburn AE. Lee WH. Elledge SJ. Genes Dev 7: 555-569 (1993)  [RAB]
	E2F and Rb interact - Shirodkar S. Ewen M. DeCaprio JA. Morgan J. Livingston DM. Chittenden T. Cell 68: 157-66 (1992)  [DLS]

Locus: TP53

Topic: Protein Binding

	p89 p89 is a tyrosine phosphorylated protein that associates with c-src in mammary epithelial cells. - Muthuswamy SK. Muller WJ. Oncogene 11: 1801-1810 (1995)  [RAB]
	Tyrosine phosphorylated Neu - Muthuswamy SK. Muller WJ. Oncogene 11: 1801-1810 (1995)  [RAB]
	Tyrosine phosphorylated Neu - Muthuswamy SK. Muller WJ. Oncogene 11: 271-279 (1995)  [RAB]

Locus: TSG101

Topic: Protein Binding

Stathmin interacts w coiled-coil domain Stathmin is a cytosolic phosphoprotein. - Li L. Cohen SN. Cell 85: 319-329 (1996)  [RAB]

Our primary goal in this database is to make as much information available as quickly as possible. We also intend to correctly cite this information. Sometimes we encounter a fact in a paper which does not come from that paper but rather is a reference to earlier work. This fact may or may not be referenced or even published. For the sake of completeness, we may include this fact, but flag it as a secondary fact, in contrast to a primary fact reported in the cited paper.

Also, sometimes we extract facts by reading the full paper, and sometimes from reading the abstract. Clearly the former is more reliable.

Finally, we distinguish between research papers and reviews.

The code we use to flag this different cases is as follows:

Primary Fact from a Full Paper

Primary Fact from an Abstract

Secondary Fact from a Full Paper

Secondary Fact from an Abstract

Primary Fact from a Review

Secondary Fact from a Review

Unknown

Curator initials are given in [brackets] at the end of each fact. The curators are: RAB = Rudeina A. Baasiri, Ph.D. , SSC = Steven S. Chua , DLS = David Steffen, Ph.D. .